COVID-19’s omicron variant is highly transmissible. It weakened vaccines’ defense against infection, though the shots still confer strong protection against severe illness. In addition, two of three widely used monoclonal antibody treatments for those infected with it are essentially ineffective.
The virus’s ability to surprise requires a medical arsenal that adapts nimbly as well. Given that, it’s time for the World Health Organization (WHO) and other officials to take a fresh look at a historic infectious disease treatment — convalescent plasma.
In 2020, Sen. Amy Klobuchar, D-Minn., introduced legislation to raise awareness of convalescent plasma’s importance. In 2022, this high-profile senator and former presidential candidate has an opportunity to act again, this time by aiding physicians at Johns Hopkins, Mayo Clinic and the University of Minnesota.
During the early pandemic, it was given to the very sickest patients in the hospital. While research ultimately didn’t support that use, there is solid new data from Johns Hopkins-led researchers backing its value in early treatment. Like the monoclonal antibodies, convalescent plasma could be given promptly to reduce the risk of hospitalization.
Convalescent plasma has a long history helping combat disease. Before there were antibiotics and antivirals, physicians recognized that recovering patients could help others from becoming seriously ill. The reason: the antibodies they naturally manufactured.
Blood donated by these patients can be “processed to remove blood cells, leaving behind liquid (plasma) and antibodies,’’ according to the Mayo Clinic. The antibodies can then be infused into the newly ill. It’s like having a seasoned platoon show up to assist immune system soldiers.
The WHO recently reviewed pooled research data on the therapy’s effectiveness in treating COVID-19. On Dec. 7, it updated its guidelines, recommending against its use, but said clinical trials should continue for severely ill patients.
But on Dec. 21, Johns Hopkins-led researchers posted their findings from a multicenter trial involving 1,181 patients. Unlike many other studies, they were given concentrated convalescent plasma early, not when seriously ill. The research, posted to the preprint website MedRxiv, found:
”With early administration of high-titer SARS-CoV-2 convalescent plasma reducing outpatient hospitalizations by more than 50%, our findings suggest that this is another effective treatment for COVID-19 with the advantages being low cost, wide availability and rapid resilience to the evolving SARS-CoV-2,” Johns Hopkins researcher Dr. Kelly Gebo stated.
Dr. Claudia Cohn, a University of Minnesota Medical School professor and transfusion medicine researcher, called the new findings “really good strong data.” She said it would be helpful for leaders in Washington, D.C., to ask questions about the new findings and how to boost plasma supplies.
A Klobuchar spokeswoman lauded the scientific community’s “remarkable work” and said the senator believes “regulatory agencies should vet new treatments with urgency and make them available to the public as soon as scientific evidence shows it is safe to do so.”
We hope others heed this call for help from leading medical researchers. This promising treatment deserves another look.
— Tribune News Service
